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Article

UGT1A6 polymorphisms modulated lung cancer risk in a Chinese population.

PloS one - 1 Jan 2012

Kua Ley-Fang, Ross Soo, Lee Soo-Chin, Mimura Kousaku, Kono Koji, Goh Boon-Cher, Yong Wei-Peng

Abstract excerpt

Uridine diphosphoglucuronosyltransferases (UGTs) 1A6 is the only UGT1A isoform expressed in lung tissue. It is responsible for the detoxification of carcinogens such as benezo[a]pyrene from cigarette smoke. The purpose of this study was to evaluate the association of UGT1A6 polymorphisms and haplotypes with lung cancer risk and to evaluate the functional significance of UGT1A6 polymorphisms. Genomic DNA was...

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PMID: 22912755
DOI: 10.1371/journal.pone.0042873
PMCID: PMC3422233

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