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Article

Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma.

BMC cancer - 31 Mar 2015

Mafune Aki, Hama Takanori, Suda Toshihito, Suzuki Yutaka, Ikegami Masahiro, Sakanashi Chikako, Imai Satoko, Nakashima Akio, Yokoo Takashi, Wada Kota, Kojima Hiromi, Urashima Mitsuyoshi

Abstract excerpt

BACKGROUND: Smoking induces oncogenic TP53-mutations in head and neck squamous cell carcinomas (HNSCCs). Disruptive mutations of TP53-gene and expression of p16 protein [p16 (+)] in tumor tissue associate with worse and better prognosis, respectively. UDP-glucuronosyltransferase 2 family, polypeptide B17 (UGT2B17) detoxifies smoking-related metabolites. Differences among ethnic groups in UGT2B17 are extremely...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25886176
DOI: 10.1186/s12885-015-1220-2
PMCID: PMC4389803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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