Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.

doi:10.3109/03602532.2015.1131292

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Article

Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.

Drug metabolism reviews - 1 Jan 2016

Hu Dong Gui, Mackenzie Peter I, McKinnon Ross A, Meech Robyn

Abstract excerpt

Identification of genetic polymorphisms that contribute to the risk of developing cancers is important for cancer prevention. The most recent human genome GRCh38/hg38 assembly (2013) reveals thousands of genetic polymorphisms in human uridine diphosphoglucuronosyltransferase (UGT) genes. Among these, a large number of polymorphisms at the UGT1A and UGT2B genes have been shown to modulate UGT gene promoter...

Topics

Genetic Predisposition to Disease
Glucuronosyltransferase
Humans
Neoplasms
Polymorphism, Single Nucleotide

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Open in PubMed

Identifiers

PMID: 26828111
DOI: 10.3109/03602532.2015.1131292

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