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Article

Association between UGT1A12828 genotype and lung cancer in the Japanese population.

International journal of clinical oncology - 1 Apr 2017

Nishikawa Yoshitaka, Kanai Masashi, Narahara Maiko, Tamon Akiko, Brown J B, Taneishi Kei, Nakatsui Masahiko, Okamoto Kazuya, Uneno Yu, Yamaguchi Daisuke, Tomono Teruko, Mori Yukiko, Matsumoto Shigemi, Okuno Yasushi, Muto Manabu

Abstract excerpt

BACKGROUND: Lung cancer is the leading cause of cancer death and is closely linked to tobacco smoking. Genetic polymorphisms in genes that encode enzymes involved in metabolizing tobacco carcinogens could affect an individual's risk for lung cancer. While polymorphism of UDP-glucuronosyltransferase1A1 (UGT1A1) is involved in detoxification of benzo(a)pyrene-7,8-dihydrodiol(-), a major tobacco carcinogen, the...

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PMID: 27832386
DOI: 10.1007/s10147-016-1061-2

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