Article
Allelic variants in the zinc transporter-3 gene, SLC30A3, a candidate gene identified from gene expression studies, show gender-specific association with schizophrenia.
European psychiatry : the journal of the Association of European Psychiatrists - 1 Mar 2014
Perez-Becerril C, Morris A G, Mortimer A, McKenna P J, de Belleroche J
Abstract excerpt
Previous microarray analysis of gene expression in frontal cortex showed differential expression of genes associated with synaptic function in schizophrenia compared to matched-controls in two independent cohorts. One of these genes validated in both cohorts, SLC30A3, which encodes the Zinc Transporter 3 (ZNT3), is localised to synaptic vesicles in glutamate synapses and known to be involved in cognitive...
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