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Functional variants fine-mapping and gene function characterization provide insights into the role of ZNF323 in schizophrenia pathogenesis.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2021

Li Shiwu, Li Xiaoyan, Liu Jiewei, Huo Yongxia, Li Long, Wang Junyang, Luo Xiong-Jian

Abstract excerpt

Schizophrenia is a severe mental disease characterized with positive symptoms, negative symptoms, and cognitive impairments. Although recent genome-wide association studies (GWASs) have identified over 145 risk loci for schizophrenia, pinpointing the causal variants and genes at the reported loci and elucidating their roles in schizophrenia remain major challenges. Here we identify a functional single-nucleotide...

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PMID: 33522098
DOI: 10.1002/ajmg.b.32835

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