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Article

The Role of SLC39A8.p.(Ala391Thr) in Schizophrenia Symptom Severity and Cognitive Ability: Cross-Sectional Studies of Schizophrenia and the General UK Population.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2025

Smart Sophie E, Legge Sophie E, Fenner Eilidh, Pardiñas Antonio F, Woolway Grace, Lynham Amy J, Escott-Price Valentina, Hall Jeremy, Wilkinson Lawrence, Holmans Peter, O'Donovan Michael C, Owen Michael J, Walters James T R

Abstract excerpt

The missense SNP NC_000004.12:g.102267552C>T (also known as SLC39A8.p.(Ala391Thr), rs13107325) in SLC39A8 encodes a zinc transporter. This SNP has been linked to schizophrenia and is the likely causal variant for one of the genome-wide association loci associated with the disorder. Using regression analyses, we tested whether the schizophrenia-risk allele at p.(Ala391Thr) was associated with schizophrenia-related...

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Share to Cation Transport Proteins
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Source

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Identifiers

PMID: 40530585
DOI: 10.1002/ajmg.b.33037
PMCID: PMC12281500

Genes

SLC39A8

Variants

Provenance

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