Article
Loss of synaptic Zn2+ transporter function increases risk of febrile seizures.
Scientific reports - 9 Dec 2015
Hildebrand Michael S, Phillips A Marie, Mullen Saul A, Adlard Paul A, Hardies Katia, Damiano John A, Wimmer Verena, Bellows Susannah T, McMahon Jacinta M, Burgess Rosemary, Hendrickx Rik, Weckhuysen Sarah, Suls Arvid, De Jonghe Peter, Scheffer Ingrid E, Petrou Steven, Berkovic Samuel F, Reid Christopher A
Abstract excerpt
Febrile seizures (FS) are the most common seizure syndrome and are potentially a prelude to more severe epilepsy. Although zinc (Zn(2+)) metabolism has previously been implicated in FS, whether or not variation in proteins essential for Zn(2+) homeostasis contributes to susceptibility is unknown. Synaptic Zn(2+) is co-released with glutamate and modulates neuronal excitability. SLC30A3 encodes the zinc...
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