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Article

Schizophrenia-associated rs4702 G allele-specific downregulation of FURIN expression by miR-338-3p reduces BDNF production.

Schizophrenia research - 1 Sept 2018

Hou Yu, Liang Wenquan, Zhang Jian, Li Qiyang, Ou Haiyan, Wang Zhongju, Li Shufen, Huang Xingbing, Zhao Cunyou

Abstract excerpt

Genome-wide association studies (GWAS) reveal numerous schizophrenia (SCZ)-associated single-nucleotide polymorphisms (SNPs); however, functional characterizations of the risk variants remain to be established. Using data from 108 SCZ GWAS loci, we performed systematic miRNA binding site screening of 128 SCZ-associated SNPs and found that 2 out of 3 SNPs located in the 3'UTR were predicted to alter 3 miRNAs'...

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Identifiers

PMID: 29499969
DOI: 10.1016/j.schres.2018.02.040

Genes

FURIN
BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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