Article
Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function.
Schizophrenia bulletin - 1 Nov 2015
Luo Xiong-Jian, Mattheisen Manuel, Li Ming, Huang Liang, Rietschel Marcella, Børglum Anders D, Als Thomas D, van den Oord Edwin J, Aberg Karolina A, Mors Ole, Mortensen Preben Bo, Luo Zhenwu, Degenhardt Franziska, Cichon Sven, Schulze Thomas G, Nöthen Markus M, Su Bing, Zhao Zhongming, Gan Lin, Yao Yong-Gang
Abstract excerpt
Genome-wide association studies have identified multiple risk variants and loci that show robust association with schizophrenia. Nevertheless, it remains unclear how these variants confer risk to schizophrenia. In addition, the driving force that maintains the schizophrenia risk variants in human gene pool is poorly understood. To investigate whether expression-associated genetic variants contribute to...
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