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Article

Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling.

Translational psychiatry - 19 Feb 2021

Tseng Wei Chou, Reinhart Veronica, Lanz Thomas A, Weber Mark L, Pang Jincheng, Le Kevin Xuong Vinh, Bell Robert D, O'Donnell Patricio, Buhl Derek L

Abstract excerpt

Schizophrenia is a complex and heterogenous disease that presents with abnormalities in glutamate signaling and altered immune and inflammatory signals. Genome-wide association studies have indicated specific genes and pathways that may contribute to schizophrenia. We assessed the impact of the functional missense variant SLC39A8 (ZIP8)-A391T (ZIP8A391T) on zinc transport, glutamate signaling, and the...

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PMID: 33608496
DOI: 10.1038/s41398-021-01262-5
PMCID: PMC7895948

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