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Article

The absence of Brm exacerbates photocarcinogenesis.

Experimental dermatology - 1 Aug 2012

Halliday Gary M, Zhou Yue, Sou Paul W, Huang Xiao X J, Rana Sabita, Bugeja Matthew J, Painter Nicole, Scolyer Richard A, Muchardt Christian, Di Girolamo Nick, Lyons J Guy

Abstract excerpt

Brm is an ATPase subunit of the SWI/SNF chromatin-remodelling complex. Previously, we identified a novel hotspot mutation in Brm in human skin cancer, which is caused by exposure to ultraviolet radiation (UVR). As SWI/SNF is involved in DNA repair, we investigated whether Brm-/- mice had enhanced photocarcinogenesis. P53+/- and Brm-/-p53+/- mice were also examined as the p53 tumor suppressor gene is mutated early...

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Source

Identifiers

PMID: 22775994
DOI: 10.1111/j.1600-0625.2012.01522.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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