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Article

Targeting mutant p53 shows promise for sunscreens and skin cancer.

The Journal of clinical investigation - 1 Dec 2007

El-Deiry Wafik S

Abstract excerpt

Chronic exposure to UV light is a risk factor for skin cancer in which signature mutations in the p53 tumor suppressor gene occur due to DNA damage and contribute to cancer development. In this issue of the JCI, Tang et al. report on their study of a nonimmunodeficient mouse model of UVB-induced skin cancer and human skin carcinoma cells and show that the mutant p53 conformation-modifying drug CP-31398 not only...

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Identifiers

PMID: 18060027
DOI: 10.1172/JCI34251
PMCID: PMC2096462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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