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Article

Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Aug 2018

Yin Lei, Yu Xiaozhong

Abstract excerpt

Arsenic is a well-known environmental carcinogen and an effective chemotherapeutic agent. The underlying mechanism of this dual-effect, however, is not fully understood. In this study, we applied mouse p53+/+ and p53-/- cells to examine the NFκB pathway and proinflammatory cytokines after arsenic treatment. Arsenic reduced cell viability and increased more apoptosis in the p53-/- cells as compared to p53+/+...

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Identifiers

PMID: 29944914
DOI: 10.1016/j.fct.2018.06.053
PMCID: PMC6689409

Genes

ATF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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