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Article

Prostacyclin and PPARα agonists control vascular smooth muscle cell apoptosis and phenotypic switch through distinct 14-3-3 isoforms.

PloS one - 1 Jan 2013

Chen Yen-Chung, Chu Ling-Yun, Yang Shu-Fan, Chen Hua-Ling, Yet Shaw-Fang, Wu Kenneth K

Abstract excerpt

We hypothesized that prostacyclin (PGI2) protects vascular smooth muscle cell (VSMC) against apoptosis and phenotypic switch through peroxisome proliferator-activated receptor-α (PPARα) activation and 14-3-3 upregulation. Here we showed that transfection of rat aortic VSMC, A-10, with PGI2-producing vectors, Ad-COPI, resulted in attenuated H2O2-induced apoptosis accompanied by a selective increase in 14-3-3β and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Identifiers

PMID: 23844263
DOI: 10.1371/journal.pone.0069702
PMCID: PMC3701049

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SRF

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