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Article

[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.

Human & experimental toxicology - 1 Jan 2000

Xie Yi, Zhang Jin, Zhang Min, Jiang Li

Abstract excerpt

Angiotensin II (AngII) is involved in the pathogenesis of hypertensive artery remodeling by inducing a phenotypic switch in vascular smooth muscle cells [Gly14]-Humanin (HNG), a humanin analogue, exerts potent cytoprotective effects both in vitro and in vivo. This study aimed to investigate the effects of HNG on an AngII-induced phenotypic switch in VSMCs and the potential mechanisms underlying these effects. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36289015
DOI: 10.1177/09603271221136208

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