Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation.

doi:10.1016/j.immuni.2017.01.006

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Article

Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation.

Immunity - 21 Feb 2017

Calippe Bertrand, Augustin Sebastien, Beguier Fanny, Charles-Messance Hugo, Poupel Lucie, Conart Jean-Baptiste, Hu Shulong J, Lavalette Sophie, Fauvet Alexandre, Rayes Julie, Levy Olivier, Raoul William, Fitting Catherine, Denèfle Thomas, Pickering Matthew C, Harris Claire, Jorieux Sylvie, Sullivan Patrick M, Sahel José-Alain, Karoyan Philippe, Sapieha Przemyslaw, Guillonneau Xavier, Gautier Emmanuel L, Sennlaub Florian

Abstract excerpt

Variants of the CFH gene, encoding complement factor H (CFH), show strong association with age-related macular degeneration (AMD), a major cause of blindness. Here, we used murine models of AMD to examine the contribution of CFH to disease etiology. Cfh deletion protected the mice from the pathogenic subretinal accumulation of mononuclear phagocytes (MP) that characterize AMD and showed accelerated resolution of...

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PMID: 28228282
DOI: 10.1016/j.immuni.2017.01.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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