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Article

Eliminating Complement Factor D Reduces Photoreceptor Susceptibility to Light-Induced Damage

25 Oct 2007

Abstract excerpt

PURPOSE: Genetic risk factors such as variations in complement factors H (CFH) and B (CFB) have been implicated in the etiology of age-related macular degeneration. It has been hypothesized that inadequate control of complement-driven inflammation may be a major factor in disease pathogenesis. The authors tested the involvement of the complement system in an experimental model for oxidative stress-mediated...

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Identifiers

PMID: 17962484
DOI: 10.1167/iovs.07-0282

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