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Article

Kindlin-2 interacts with a highly conserved surface of ILK to regulate focal adhesion localization and cell spreading

25 Sept 2018

Abstract excerpt

The integrin-associated adaptor proteins integrin-linked kinase (ILK) and kindlin-2 play central roles in integrin signaling and control of cell morphology. A direct ILK-kindlin-2 interaction is conserved across species and involves the F2PH subdomain of kindlin-2 and the pseudokinase domain (pKD) of ILK. However, complete understanding of the ILK-kindlin-2 interaction and its role in integrin-mediated signaling...

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PMID: 30254023
DOI: 10.1242/jcs.221184

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