Integrin-linked kinase at a glance

Abstract excerpt

Integrins are a large family of cell–extracellular matrix (ECM) and cell–cell adhesion molecules that regulate development and tissue homeostasis by controlling cell migration, survival, proliferation and differentiation (Hynes, 2002). They are non-covalently associated heterodimers consisting of α- and β-subunits. On the cell surface, integrins exist in a conformation with either high (active) or low (inactive)...

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