Article
Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane.
The Journal of cell biology - 5 Mar 2001
Zervas C G, Gregory S L, Brown N H
Abstract excerpt
Integrin-linked kinase (ILK) was identified by its interaction with the cytoplasmic tail of human beta1 integrin and previous data suggest that ILK is a component of diverse signaling pathways, including integrin, Wnt, and protein kinase B. Here we show that the absence of ILK function in Drosophila causes defects similar to loss of integrin adhesion, but not similar to loss of these signaling pathways. ILK...
Topics
- Actins
- Amino Acid Sequence
- Animals
- Catalytic Domain
- Cell Adhesion
- Cell Membrane
- Cytoskeletal Proteins
- Cytoskeleton
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Humans