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Article

Extensive variation in gene copy number at the killer immunoglobulin-like receptor locus in humans.

PloS one - 1 Jan 2013

Vendelbosch Sanne, de Boer Martin, Gouw Remko A T W, Ho Cynthia K Y, Geissler Judy, Swelsen Wendy T N, Moorhouse Michael J, Lardy Neubury M, Roos Dirk, van den Berg Timo K, Kuijpers Taco W

Abstract excerpt

Killer immunoglobulin-like receptors (KIRs) are involved in the regulation of natural killer cell cytotoxicity. Within the human genome seventeen KIR genes are present, which all contain a large number of allelic variants. The high level of homology among KIR genes has hampered KIR genotyping in larger cohorts, and determination of gene copy number variation (CNV) has been difficult. We have designed a multiplex...

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Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Multiplex Polymerase Chain Reaction

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Source

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Identifiers

PMID: 23840750
DOI: 10.1371/journal.pone.0067619
PMCID: PMC3695908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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