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Article

Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors.

Genome research - 1 Oct 2012

Jiang Wei, Johnson Chris, Jayaraman Jyothi, Simecek Nikol, Noble Janelle, Moffatt Miriam F, Cookson William O, Trowsdale John, Traherne James A

Abstract excerpt

The KIR complex appears to be evolving rapidly in humans, and more than 50 different haplotypes have been described, ranging from four to 14 KIR loci. Previously it has been suggested that most KIR haplotypes consist of framework genes, present in all individuals, which bracket a variable number of other genes. We used a new technique to type 793 families from the United Kingdom and United States for both the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22948769
DOI: 10.1101/gr.137976.112
PMCID: PMC3460180

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Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors.PMID 22948769Read ↗

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