Article
The genomic organization and evolution of the natural killer immunoglobulin-like receptor (KIR) gene cluster.
Immunogenetics - 1 Apr 2000
Martin A M, Freitas E M, Witt C S, Christiansen F T
Abstract excerpt
Natural killer (NK) immunoglobulin-like receptors (KIRs) are a family of polymorphic receptors which interact with specific motifs on HLA class I molecules and modulate NK cytolytic activity. In this study, we analyzed a recently sequenced subgenomic region on chromosome 19q13.4 containing eight members of the KIR receptor repertoire. Six members are clustered within a 100-kb continuous sequence. These genes...
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