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Article

Stochastic Tunneling of Two Mutations in a Population of Cancer Cells.

PloS one - 1 Jan 2013

Haeno Hiroshi, Maruvka Yosef E, Iwasa Yoh, Michor Franziska

Abstract excerpt

Cancer initiation, progression, and the emergence of drug resistance are driven by specific genetic and/or epigenetic alterations such as point mutations, structural alterations, DNA methylation and histone modification changes. These alterations may confer advantageous, deleterious or neutral effects to mutated cells. Previous studies showed that cells harboring two particular alterations may arise in a...

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PMID: 23840359
DOI: 10.1371/journal.pone.0065724
PMCID: PMC3694076

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