Article
Stochastic tunnels in evolutionary dynamics.
Genetics - 1 Mar 2004
Iwasa Yoh, Michor Franziska, Nowak Martin A
Abstract excerpt
We study a situation that arises in the somatic evolution of cancer. Consider a finite population of replicating cells and a sequence of mutations: type 0 can mutate to type 1, which can mutate to type 2. There is no back mutation. We start with a homogeneous population of type 0. Mutants of type 1 emerge and either become extinct or reach fixation. In both cases, they can generate type 2, which also can become...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.