Temporal order of mutations influences cancer initiation dynamics

Abstract excerpt

Cancer is a set of genetic diseases that are driven by mutations. It was recently discovered that the temporal order of genetic mutations affects the cancer evolution and even the nature of the decease itself. The mechanistic origin of these observations, however, remain not well understood. Here we present a theoretical model for cancer initiation dynamics that allows us to quantify the impact of the temporal ord...

Topics

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• Cell Transformation, Neoplastic
• Computer Simulation
• Models, Biological
• Models, Genetic
• Monte Carlo Method
• Mutation
• Neoplasms
• Stochastic Processes

Identifiers and source

Literature Corpus work

69b00374-a5b8-57e2-8191-b128daa51e3d

DOI

10.1101/2021.01.10.426139