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Article

Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes.

The Journal of pathology - 1 Oct 2009

Wang Jinxi, Gardner Brian M, Lu Qinghua, Rodova Marianna, Woodbury Brent G, Yost John G, Roby Katherine F, Pinson David M, Tawfik Ossama, Anderson Harrison C

Abstract excerpt

Osteoarthritis (OA) is the most common form of joint disease in middle-aged and older individuals. Previous studies have shown that over-expression of matrix-degrading proteinases and proinflammatory cytokines is associated with osteoarthritic cartilage degradation. However, it remains unclear which transcription factors regulate the expression of these cartilage-degrading molecules in articular chondrocytes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19526482
DOI: 10.1002/path.2578
PMCID: PMC2975457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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