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Article

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

3 Jun 2019

Abstract excerpt

The WW domain-containing protein 2 (Wwp2) gene, the host gene of miR-140, codes for the Wwp2 protein, which is an HECT-type E3 ubiquitin ligases abundantly expressed in articular cartilage. However, its function remains unclear. Here, we show that mice lacking Wwp2 and mice in which the Wwp2 E3 enzyme is inactivated (Wwp2-C838A) exhibit aggravated spontaneous and surgically induced osteoarthritis (OA). Consistent...

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PMID: 31160553
DOI: 10.1038/s41467-019-10177-1

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