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Article

Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-κB (NF-κB) Family Member RelA/p65 in Chondrocytes during Osteoarthritis Development

21 Aug 2013

Abstract excerpt

Background: ADAMTS5 is a crucial proteinase for osteoarthritis development. Results: NF-κB family member RelA/p65 was identified as a potent transactivator of ADAMTS5 and regulated the expression and aggrecanolysis. Conclusion: RelA/p65 is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development. Significance: The molecular network related to the RelA/p65-ADAMTS5 axis may...

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PMID: 23963448
DOI: 10.1074/jbc.m113.452169

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