Article
The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa.
Antimicrobial agents and chemotherapy - 1 Sept 2013
Okombo John, Zongo Issaka, Gadalla Nahla, Bousema Teun, Beshir Khalid B, Roper Cally, Hallett Rachel, Ochola-Oyier Lynette Isabella, Sutherland Colin J
Abstract excerpt
Sequence variation in the asparagine/aspartate-rich domain of pfmdr1 in 215 isolates of Plasmodium falciparum from three African countries was compared with published data. The role of this domain in modulating antimalarial sensitivity has not been established. The pfmdr1 86Y allele was significantly associated with different configurations of the Asn/Asp-rich domain in West and East Africa. In Kenya, a specific...
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