Evolutionary diversity of the pfmdr1 hinge region and association with antimalarial drug resistance mutations post ACT introduction.

doi:10.1016/j.ijpddr.2026.100662

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Article

Evolutionary diversity of the pfmdr1 hinge region and association with antimalarial drug resistance mutations post ACT introduction.

International journal for parasitology. Drugs and drug resistance - 1 Aug 2026

Hocke Emma Filtenborg, Hansson Helle, Chopo-Pizarro Ana, Wellmann Louise, Kahunu Gauthier Mesia, Mavoko Hypolite Muhindo, Nkoli Papy Mandoko, Sompwe Eric Mukomena, Mbongi Destin, Mitashi Patrick, Ali Innocent Mbulli, Nji Akindeh, Mbacham Wilfred, Moussiliou Azizath, Dandonougbo Codjo, Kpemasse Augustin, Affoukou Cyriaque, Akogbeto Martin, Ngufor Corine, Beshir Khalid, Mousa Andria, Roper Cally, Sutherland Colin J, Alifrangis Michael

Abstract excerpt

The Plasmodium falciparum multidrug resistance-1 (pfmdr1) gene, which encodes the ABC P-glycoprotein homolog PgH1, accumulates mutations that result in amino acid changes, namely single-nucleotide polymorphisms at codons N86Y, Y184F, and D1246Y, associated with altered parasite susceptibility to multiple antimalarial drugs. Among these antimalarials are compounds used in artemisinin-based combination (ACT)...

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PMID: 42561758
DOI: 10.1016/j.ijpddr.2026.100662
PMCID: PMC13471704

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