Article
pfmdr1 mutations in imported African Plasmodium falciparum isolates.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Nov 2008
Dippmann Anja K, Bienzle Ulrich, Harms Gundel, Mockenhaupt Frank P
Abstract excerpt
Amodiaquine/artesunate and artemether/lumefantrine are currently implemented as antimalarial drugs in Africa. In this study, we assessed Plasmodium falciparum pfmdr1 alleles suggesting reduced sensitivity to amodiaquine/artesunate (86Y-184Y-1246Y) and artemether/lumefantrine (184F and 86N-184F-1246D) in 111 African isolates imported to Germany between 1997 and 2005. pfmdr1 86Y-184Y-1246Y occurred less frequently...
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