Article
Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine.
Parasitology - 1 Mar 1997
Duraisingh M T, Drakeley C J, Muller O, Bailey R, Snounou G, Targett G A, Greenwood B M, Warhurst D C
Abstract excerpt
The 4-aminoquinolines chloroquine (CQ) and amodiaquine (AM) were used to treat Gambian children with uncomplicated falciparum malaria in a randomized drug trial. Blood samples were taken immediately before treatment (day 0), and at day 7 and day 28 after treatment. Samples from those parasitologically positive at day 7 following treatment ('early positives') and those positive at day 28 but negative at day 7...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- Amodiaquine
- Animals
- Antimalarials
- Child
- Child, Preschool
- Chloroquine
- Codon
- Drug Resistance
- Genes, Protozoan
- Humans
- Infant
- Malaria, Falciparum