Article
The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin.
Molecular and biochemical parasitology - 30 Apr 2000
Duraisingh M T, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst D C
Abstract excerpt
Although chloroquine-resistance (CQR) in Plasmodium falciparum is increasing and resistance to other blood schizonticidal anti-malarials has been reported, the molecular basis remains unclear. In this study fresh field isolates were obtained from The Gambia, an area of emerging CQR and tested for sensitivity to the anti-malarial drugs mefloquine, halofantrine, artemisinin, dihydroartemisinin, chloroquine and...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- Animals
- Antimalarials
- Artemisinins
- Humans
- Malaria, Falciparum
- Mefloquine
- Plasmodium falciparum
- Polymerase Chain Reaction