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Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

2023-07-19

Abstract excerpt

Obesity substantially increases the risk of type 2 diabetes, cardiovascular disease, and other diseases, making it a leading preventable cause of death in developed countries. It has a strong genetic basis, with obesity-associated genetic variants preferentially acting in the brain. This includes the hypothalamic pro-opiomelanocortin (POMC) neurons that inhibit food intake and are stimulated by drugs that agonise...

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Literature Corpus work
3d495486-f451-55f7-baf4-c0c6ce12c7cb
DOI
10.1101/2023.07.18.549357
Open publication

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Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight lossDOI 10.1101/2023.07.18.549357
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