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Article

Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations.

Proceedings of the National Academy of Sciences of the United States of America - 23 Apr 2013

Zheng Ruimao, Yang Linghai, Sikorski Maria A, Enns Linda C, Czyzyk Traci A, Ladiges Warren C, McKnight G Stanley

Abstract excerpt

Targeted disruption of RIIβ-protein kinase A (PKA) in mice leads to a lean phenotype, increased nocturnal locomotor activity, and activation of brown adipose tissue. Because RIIβ is abundantly expressed in both white and brown adipose tissue as well as the brain, the contribution of neuronal vs. peripheral PKA to these phenotypes was investigated. We used a Cre-Lox strategy to reexpress RIIβ in a tissue-specific...

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Identifiers

PMID: 23569242
DOI: 10.1073/pnas.1219542110
PMCID: PMC3637730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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