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Article

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

The Journal of clinical investigation - 1 Dec 2005

de Luca Carl, Kowalski Timothy J, Zhang Yiying, Elmquist Joel K, Lee Charlotte, Kilimann Manfred W, Ludwig Thomas, Liu Shun-Mei, Chua Streamson C

Abstract excerpt

We have generated mice that carry a neuron-specific leptin receptor (LEPR) transgene whose expression is driven by the rat synapsin I promoter synapsin-LEPR B (SYN-LEPR-B). We have also generated mice that are compound hemizygotes for the transgenes SYN-LEPR-B and neuron-specific enolase-LEPR B (NSE-LEPR-B). We observed a degree of correction in db/db mice that are hemizygous (Syn db/db) and homozygous (Syn/Syn...

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Identifiers

PMID: 16284652
DOI: 10.1172/JCI24059
PMCID: PMC1280964

Genes

LEPR

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