Article
Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.
Diabetologia - 1 Apr 2014
Sasaki Tsutomu, Kikuchi Osamu, Shimpuku Mayumi, Susanti Vina Yanti, Yokota-Hashimoto Hiromi, Taguchi Ryo, Shibusawa Nobuyuki, Sato Takashi, Tang Lijun, Amano Kosuke, Kitazumi Tomoya, Kuroko Mitsutaka, Fujita Yuki, Maruyama Jun, Lee Yong-Soo, Kobayashi Masaki, Nakagawa Takashi, Minokoshi Yasuhiko, Harada Akihiro, Yamada Masanobu, Kitamura Tadahiro
Abstract excerpt
AIMS/HYPOTHESIS: Obesity is associated with ageing and increased energy intake, while restriction of energy intake improves health and longevity in multiple organisms; the NAD(+)-dependent deacetylase sirtuin 1 (SIRT1) is implicated in this process. Pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons in the arcuate nucleus (ARC) of the hypothalamus are critical for energy balance regulation, and...
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