Article
PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.
PloS one - 1 Jan 2011
Cao Yongheng, Nakata Masanori, Okamoto Shiki, Takano Eisuke, Yada Toshihiko, Minokoshi Yasuhiko, Hirata Yukio, Nakajima Kazunori, Iskandar Kristy, Hayashi Yoshitake, Ogawa Wataru, Barsh Gregory S, Hosoda Hiroshi, Kangawa Kenji, Itoh Hiroshi, Noda Tetsuo, Kasuga Masato, Nakae Jun
Abstract excerpt
Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1). However, little is known about whether PDK1 in agouti-related peptide (AGRP) neurons contributes to energy homeostasis. We generated AGRP neuron-specific PDK1 knockout (AGRPPdk1(-/-)) mice and mice with selective expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.