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Article

APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.

Biological psychiatry - 1 May 2014

Gomar Jesus J, Gordon Marc L, Dickinson Dwight, Kingsley Peter B, Uluğ Aziz M, Keehlisen Lynda, Huet Sarah, Buthorn Justin J, Koppel Jeremy, Christen Erica, Conejero-Goldberg Concepcion, Davies Peter, Goldberg Terry E

Abstract excerpt

BACKGROUND: Proton magnetic resonance spectroscopy ((1)H-MRS) studies on healthy aging have reported inconsistent findings and have not systematically taken into account the possible modulatory effect of APOE genotype. We aimed to quantify brain metabolite changes in healthy subjects in relation to age and the presence of the APOE E4 genetic risk factor for Alzheimer's disease. Additionally, we examined these...

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Identifiers

PMID: 23831342
DOI: 10.1016/j.biopsych.2013.05.022
PMCID: PMC3887136

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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