Article
H 435‐containing immunoglobulin G 3 allotypes are transported efficiently across the human placenta: implications for alloantibody‐mediated diseases of the newborn
7 Jul 2013
Abstract excerpt
BACKGROUND: The neonatal receptor (FcRn) extends the half-life of human immunoglobulin (Ig)G and transports it across the placenta, providing the newborn with humoral immunity. Of the four subclasses, IgG3 stands out with strong effector functions, short half-life (7 days vs. 21 days for other subclasses), and poor placental transport. We recently described how a single-amino-acid polymorphism at Position 435 in...