Article
Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge.
Scientific reports - 14 May 2019
Stapleton Nigel M, Brinkhaus Maximilian, Armour Kathryn L, Bentlage Arthur E H, de Taeye Steven W, Temming A Robin, Mok Juk Yee, Brasser Giso, Maas Marielle, van Esch Wim J E, Clark Mike R, Williamson Lorna M, van der Schoot C Ellen, Vidarsson Gestur
Abstract excerpt
Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower foetal than maternal concentration at term, despite all known FcRn binding residues being preserved between IgG1...
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