Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans.

International immunology - 1 Aug 2001

Firan M, Bawdon R, Radu C, Ober R J, Eaken D, Antohe F, Ghetie V, Ward E S

Abstract excerpt

The transfer of maternal gamma-globulin (IgG) provides the neonate with humoral immunity during early life. In humans, maternal IgG is transported across the placenta during the third trimester of pregnancy. The expression of the MHC class I-related receptor, FcRn, in the human placenta suggests that this Fc receptor might be involved in the delivery of maternal IgG, but direct evidence to support this is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites, Antibody
Share to Half-Life

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Immunoglobulin G

Share to Maternal-Fetal Exchange

Share to Placenta

Share to Receptors, Fc

Share to Receptors, IgG

Source

Identifiers

PMID: 11470769
DOI: 10.1093/intimm/13.8.993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans.PMID 11470769Read ↗

Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functionsSemantic proximity Read ↗

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodiesSemantic proximity Read ↗

Multiple Roles for the Major Histocompatibility Complex Class I– Related Receptor FcRnSemantic proximity Read ↗

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodiesSemantic proximity Read ↗

Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport.Semantic proximity Read ↗

The immunologic functions of the neonatal Fc receptor for IgG.Semantic proximity Read ↗

Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic ImplicationsSemantic proximity Read ↗

A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus.Semantic proximity Read ↗

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinitySemantic proximity Read ↗

Contribution of the ex vivo placental perfusion model in understanding transplacental immunoglobulin G transferSemantic proximity Read ↗

Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering.Semantic proximity Read ↗

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.