Article
Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin.
PLoS medicine - 1 Oct 2017
Dechavanne Celia, Dechavanne Sebastien, Sadissou Ibrahim, Lokossou Adjimon Gatien, Alvarado Fernanda, Dambrun Magalie, Moutairou Kabirou, Courtin David, Nuel Gregory, Garcia Andre, Migot-Nabias Florence, King Christopher L
Abstract excerpt
BACKGROUND: Transplacental transfer of maternal immunoglobulin G (IgG) to the fetus helps to protect against malaria and other infections in infancy. Recent studies have emphasized the important role of malaria-specific IgG3 in malaria immunity, and its transfer may reduce the risk of malaria in infancy. Human IgGs are actively transferred across the placenta by binding the neonatal Fc receptor (FcRn) expressed...
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