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Article

Lysosome-mediated processing of chromatin in senescence

1 Jul 2013

Abstract excerpt

Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are important for recycling of cellular constituents and cell remodeling. Here we show that an autophagy/lysosomal pathway processes chromatin in senescent cells. In...

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PMID: 23816621
DOI: 10.1083/jcb.201212110

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