Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence

Abstract excerpt

Cellular senescence is a largely irreversible form of cell cycle arrest triggered by various types of damage and stress, including oncogene expression (termed oncogene-induced senescence or OIS). We and others have previously demonstrated that OIS occurs in human benign lesions, acting as a potent tumor suppressor mechanism. Numerous phenotypic changes occur during OIS, both in the cytoplasm and in the nucleus....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomics and Chromatin Dynamics
• Share to Nuclear Structure and Function
• Share to Telomeres, Telomerase, and Senescence