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Article

H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China.

European journal of neurology - 1 Feb 2011

He X, Lu X, Hu J, Xi J, Zhou D, Shang H, Liu L, Zhou H, Yan B, Yu L, Hu F, Liu Z, He L, Yao X, Xu Y

Abstract excerpt

BACKGROUND AND PURPOSE: The H63D polymorphism in the hemochromatosis (HFE) gene has been reported as a risk factor for amyotrophic lateral sclerosis (ALS) in Europe and America, but no data have been reported for Asia. Here, we investigated the possible association between H63D and sporadic ALS (sALS) in a Chinese Han population. METHODS: A total of 195 individuals with sALS from three centers in China and 405...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20642794
DOI: 10.1111/j.1468-1331.2010.03158.x

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China.PMID 20642794Read ↗

H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population.Semantic proximity Read ↗

Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies.Semantic proximity Read ↗

No evidence of association between polymorphisms in four genes and sporadic amyotrophic lateral sclerosis in Han Chinese.Semantic proximity Read ↗

Polymorphisms in protein disulfide isomerase are associated with sporadic amyotrophic lateral sclerosis in the Chinese Han population.Semantic proximity Read ↗

The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population.Semantic proximity Read ↗

H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.Semantic proximity Read ↗

Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients.Semantic proximity Read ↗

Identification of TARDBP Gly298Ser as a Founder Mutation for Amyotrophic Lateral Sclerosis in Southern ChinaSemantic proximity Read ↗

Association of apolipoprotein E ε4 allele and amyotrophic lateral sclerosis in Chinese population.Semantic proximity Read ↗

HFE H63D polymorphism is increased in patients with amyotrophic lateral sclerosis of Italian originSemantic proximity Read ↗

H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients.Semantic proximity Read ↗

Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS.Semantic proximity Read ↗

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