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Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes

26 Jun 2013

Abstract excerpt

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen variant surface glycoprotein (VSG) to evade mammalian host immune responses at the bloodstream form (BF) stage. Monoallelic expression of BF Expression Site (BES)-linked VSGs and silencing of metacyclic VSGs (mVSGs) in BF cells are essential for antigenic variation, whereas silencing of both BES-linked and...

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PMID: 23804762
DOI: 10.1093/nar/gkt562

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Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changesPMID 23804762Read ↗

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T rypanosoma brucei Orc 1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switchingSemantic proximity Read ↗

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