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The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression

22 Mar 2023

Abstract excerpt

Abstract Trypanosoma brucei is a protozoan parasite that causes human African trypanosomiasis. Its major surface antigen VSG is expressed from subtelomeric loci in a strictly monoallelic manner. We previously showed that the telomere protein TbRAP1 binds dsDNA through its 737RKRRR741 patch to silence VSGs globally. How TbRAP1 permits expression of the single active VSG is unknown. Through NMR structural analysis,...

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PMID: 36949076
DOI: 10.1038/s41467-023-37307-0

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The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expressionPMID 36949076Read ↗

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